Developed with research from the world’s leading longevity dermatology experts
Each element of your program targets one or more of the six mechanisms of skin aging. Together, your personalized program forms a comprehensive system to address skin aging from multiple angles.






No more guessing what works — just the most powerful, personalized way to reverse your Skin Age
Advanced medications that renew skin at the cellular level.
The test that finally explains what’s aging your skin.
Personalized to your methylation for better sleep, less stress, and healthier skin.
Don’t just improve the appearance of skin. Renew it structurally by reversing the cellular causes of aging.
Clears out the aged cells that accumulate and inflame the tissue around them
Repairs the UV damage stored in your skin from years of exposure
Blocks the blood sugar that bonds to and stiffens collagen — a reaction that accelerates with age, even if your diet is healthy
Strengthens your skin’s defenses against free-radical damage
Quiets the low-grade inflammation degrading collagen in the background
Replenishes the coenzyme your skin cells use for repair
The Oona DNA & Methylation Test is an easy at-home test that gives you clear, actionable insights into what’s working for your skin and what needs attention — starting with methylation, the cycle your skin uses to repair DNA, build collagen, and clear damage.
We decode 54 genetic markers handpicked by our clinical team to show what’s driving your skin’s aging — and what to do about it.
See if you’re eligible
Used by your physician to tailor your prescription.
Oona turns your DNA & Methylation Test into a daily companion: your results, your superfoods, your formula, and your plan, in one place.
Your formula responds to your methylation for better sleep, less stress, and healthier skin—so you can make faster progress toward reversing your Skin Age.


You deserve ingredients held to an uncompromising standard.
Your personalized program is engineered to treat all six mechanisms of skin aging.
| Tretinoin | Vitamin C | Peptides | PDRN | Exosomes | EGF | Topical collagen | Clinic Laser | ||
|---|---|---|---|---|---|---|---|---|---|
| Cellular senescence | — | — | — | — | — | — | — | ||
| Photodamage | — | ||||||||
| Glycation | — | — | — | — | — | — | — | — | |
| Oxidative stress | — | — | — | — | — | — | |||
| Chronic inflammation | — | — | — | — | |||||
| NAD+ depletion | — | — | — | — | — | — | — | — |
“Science is showing that while chronological aging is inevitable, biological aging is malleable. There’s a part of it that you can fight, and we are getting closer and closer to winning that fight.”
Share your skin history and goals to see if an Oona program is right for you.
Once your physician approves your prescription, your medications ship right away. Your kit arrives in 3–5 business days. The cheek swab takes minutes — return it in the prepaid mailer to our CLIA-certified, CAP-accredited lab.
Your physician reviews your results and can fine-tune your dosing schedule. You get your personalized plan: your results, your superfoods, your formula, and your week-by-week roadmap to reversing your Skin Age, in one place. Your supplement formula is made from your results.
We make your supplement formula from your methylation results and ship it to your door.
Your medication dosing schedule will continue to adapt to your progress, supported by your clinical team.
Advanced injectable, oral, and topical longevity medications that treat the cellular causes of skin aging. Your physician selects and doses your prescription protocol from your Clinical Skin Analysis, and you’ll see your exact medications before you commit to anything.
Yes, your treatment requires a prescription — and the program includes it. Oona physicians, all licensed in the United States, will conduct a thorough review of your health profile to assess your suitability. Upon approval, they write your prescription, and a licensed U.S. pharmacy compounds your treatment.
Your intake covers your medical history and current medications, and your physician reviews everything before prescribing. If the protocol isn’t right for you, you won’t be charged.
No. Your physician reviews any medications you take, prescription skincare included, before writing your protocol. As with any new topical, start yours on its own and let your skin settle before layering it back in with the rest of your routine.
Some side effects are common when starting any new medication, and they usually fade as your body adjusts. Your physician starts you on conservative doses based on your Clinical Skin Analysis, and can adjust your protocol as needed.
Your physician sets your starting doses, reviews them when your DNA results come in, and adjusts them if your skin or a side effect calls for it. If you have any questions, message your care team any time, and they’ll pass anything medical to your physician.
Your sample is analyzed in a CLIA-certified, CAP-accredited U.S. lab that sequences your genome and decodes more than 70 million variants with 99% accuracy.2 Your report uses the 54 linked to skin aging.
Your DNA data is encrypted and never sold. It’s shared only with the lab that analyzes your sample, the physician who sets your prescription protocol, and the partner that makes your supplements. You can request deletion at any time.
Absolutely. You control how your genetic information is used, shared, and when it is deleted.
Yes. Your genetic information is encrypted. Your DNA sample and genetic information are secure with Oona and our CLIA-certified, CAP-accredited laboratory partner.
Yes. Your DNA & Methylation Test results are stored in a secured database. Your DNA sample is destroyed after testing and quality control checks, and you can ask us to delete your data from our systems at any time.
No. We will not use your genetic information for research.
Oona’s programs aren’t billed to insurance. You can ask your insurance provider whether you can file for reimbursement, and we’re happy to provide the paperwork. Just reach out to concierge@withoona.com.
Yes. Your supplements respond to your methylation, so every order is one of a kind. Each nutrient is chosen from clinical research for better sleep, less stress, and healthier skin.
Your supplements combine vitamins, minerals, amino acids, herbs, and food extracts. A typical daily pack contains 20+ ingredients, and your exact mix depends on your methylation results.
After your results are released, processing for your personalized supplements begins — there’s no action you need to take. They ship once they’re made.