Find out if you’re eligible for the Skin Longevity Program.

What is your primary skin goal right now?

Measure your Skin Age. Then reverse it.

  • Skin longevity medications, delivered
  • Easy at-home DNA biomarkers testing
  • Personalized plans and supplements matched to your methylation
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Methylation cycleReduced
Collagen breakdownElevated
UV responseReduced
Glycation clearanceReduced
Inflammation responseTypical
Antioxidant defenseTypical
DNA repair capacityReduced
PigmentationTypical
Barrier repairTypical
Pore supportElevated
Under-eye pigmentTypical

Developed with research from the world’s leading longevity dermatology experts

A personalized skin plan to treat skin aging beneath the surface

Each element of your program targets one or more of the six mechanisms of skin aging. Together, your personalized program forms a comprehensive system to address skin aging from multiple angles.

Aged skin cells that stopped dividing, lodged among healthy ones

Cellular senescence

Sunlight reaching into the skin and fraying the collagen beneath

Photodamage

Sugar bonding collagen fibers together and stiffening them

Glycation

Free radicals pitting skin cells faster than they repair

Oxidative stress

A low, constant immune glow wearing collagen down

Chronic inflammation

A skin cell's energy supply dimming with age

NAD+ depletion

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Everything it takes to reverse your Skin Age

No more guessing what works — just the most powerful, personalized way to reverse your Skin Age

The medical protocol

Advanced medications that renew skin at the cellular level.

Complete Skin Intelligence™ DNA & Methylation Test

The test that finally explains what’s aging your skin.

Personalized skin longevity plan and supplements

Personalized to your methylation for better sleep, less stress, and healthier skin.

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Rx Protocol DNA & Methylation Test Plan & Supplements See if you’re eligible
Rx Protocol

This is medicine, not maintenance.

Don’t just improve the appearance of skin. Renew it structurally by reversing the cellular causes of aging.

Clears senescent cells

Clears out the aged cells that accumulate and inflame the tissue around them

Targets
WrinklesFirmness
Repairs photodamage

Repairs the UV damage stored in your skin from years of exposure

Targets
Dark spotsHyperpigmentationWrinkles
Blocks glycation

Blocks the blood sugar that bonds to and stiffens collagen — a reaction that accelerates with age, even if your diet is healthy

Targets
FirmnessWrinkles
Neutralizes oxidative stress

Strengthens your skin’s defenses against free-radical damage

Targets
Surface roughnessDark spots
Calms chronic inflammation

Quiets the low-grade inflammation degrading collagen in the background

Targets
RednessHyperpigmentation
Restores NAD+

Replenishes the coenzyme your skin cells use for repair

Targets
Dark circlesSurface roughness
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DNA & Methylation Test

Your Methylation Matters

The Oona DNA & Methylation Test is an easy at-home test that gives you clear, actionable insights into what’s working for your skin and what needs attention — starting with methylation, the cycle your skin uses to repair DNA, build collagen, and clear damage.

  • Convenient at-home test kit
  • Completely painless — cheek swab, not blood
  • Actionable skin insights

We decode 54 genetic markers handpicked by our clinical team to show what’s driving your skin’s aging — and what to do about it.

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Methylation Cycle

MTHFR activityMethionine recyclingMethyl clearanceHomocysteine handling

Skin Aging Biology

Perceived facial agePhotodamage susceptibilityCollagen breakdownBarrier repairPore supportUnder-eye pigmentDNA repair capacityEyelid laxityPigmentation

Sun & Pollution

UV sensitivityPollution response

Redness & Flushing

Immune-mediated rednessInflammatory toneHistamine clearance

Medication Response

Used by your physician to tailor your prescription.

Medication metabolismMedication responseSkin barrier strengthPost-inflammatory pigmentation

Diet & Nutrients

Lactose toleranceCeliac riskGlycation clearanceB12 absorptionOmega-3 conversionVitamin A conversionIron handlingAntioxidant defense

Sleep, Stress & Training

Caffeine clearanceCaffeine sensitivityAlcohol clearanceChronotypeCortisol responseTraining response
Reviewed by board-certified physicians
Encrypted end to end. You control your data.
Analyzed in CLIA-certified, CAP-accredited U.S. labs
Plan & Supplements

Accelerate your results with a personalized plan and supplements matched to your methylation.

Your plan in your pocket

Oona turns your DNA & Methylation Test into a daily companion: your results, your superfoods, your formula, and your plan, in one place.

Step 1 of 4Health
9:41
Where your skin is aging fastest
Your DNA results on the pathways that personalize your plan
Collagen breakdownTIMP1 · COL1A1
SlowTypicalFast
People with your variant tend to break collagen down faster than they rebuild it.
DNA repair capacityXPC · ERCC2
StrongTypicalSlow
People with your variant tend to repair sun damage more slowly.
Glycation clearanceGLO1 · AGER · TCF7L2
LowTypicalHigh
People with your variant tend to clear sugar-protein bonds at the usual rate; your scan still reads elevated.
Win big with these superfoods.
Chosen from your DNA results and your scan
Start hereWild salmon
Omega-3s for a variant linked to a high inflammation response
GlycationLeafy greens
Folate and a low glycemic load
AntioxidantBlueberries
Anthocyanins for a variant linked to weak antioxidant defense
CollagenBone broth
Glycine and proline for a variant linked to fast collagen breakdown
What eating well can't do
Your formula picks up where food can't.
Your formula · 23 ingredients · made for you
Your 26-week plan to reverse your pace of skin aging
Focus, medications, superfoods, and formula, working together
FocusUndereye and eye-corner wrinkles
StartYour Rx cream, nightly
AvoidCaffeine after 2 pm
Boost5-MTHF, selenium, CoQ10, omega-3
Week 1
Start your medications. Take your test.
Your medications ship right away. Your DNA & Methylation Test takes minutes at home.
Week 2
Your results arrive. Start your routine.
Your physician can fine-tune your doses. Your formula goes into production.
Week 3
Start your supplements.
Your formula arrives.
Weeks 4–8
Hold the routine.
Texture changes first. Your week-8 scan shows where you are.

A unique formula built on your methylation

Your formula responds to your methylation for better sleep, less stress, and healthier skin—so you can make faster progress toward reversing your Skin Age.

A woman holding one Oona capsule at her lips

You deserve ingredients held to an uncompromising standard.

  • Evidence-based. Every ingredient is supported by peer-reviewed research — read the exact studies behind your formula.
  • Intentionally sourced. Every nutrient is chosen for its purity, stability, and absorption.
  • Clean by default. Vegetarian, non-GMO. No synthetic fillers, no artificial colors, no dubious additives. Ever.
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Expect real results with Oona.

BeforeAfterResults may vary.
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The real proof? It’s in the numbers.

70,000,000+
DNA variants decoded1
18,000+
Clinical trial participants
60+
Peer-reviewed studies
50+
Years of research
2
Patents pending

What makes Oona different?

Your personalized program is engineered to treat all six mechanisms of skin aging.

TretinoinVitamin CPeptidesPDRNExosomesEGFTopical collagenClinic Laser
Cellular senescence———————
Photodamage—
Glycation————————
Oxidative stress——————
Chronic inflammation————
NAD+ depletion————————
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“Science is showing that while chronological aging is inevitable, biological aging is malleable. There’s a part of it that you can fight, and we are getting closer and closer to winning that fight.”

Dr. Eric VerdinPresident and CEO, Buck Institute for Research on Aging

Here’s how it works.

Take a brief intake survey.

Share your skin history and goals to see if an Oona program is right for you.

Receive your medications and DNA & Methylation Test kit.

Once your physician approves your prescription, your medications ship right away. Your kit arrives in 3–5 business days. The cheek swab takes minutes — return it in the prepaid mailer to our CLIA-certified, CAP-accredited lab.

Get your personalized plan.

Your physician reviews your results and can fine-tune your dosing schedule. You get your personalized plan: your results, your superfoods, your formula, and your week-by-week roadmap to reversing your Skin Age, in one place. Your supplement formula is made from your results.

Receive your personalized supplements.

We make your supplement formula from your methylation results and ship it to your door.

Ongoing care and support

Your medication dosing schedule will continue to adapt to your progress, supported by your clinical team.

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Frequently asked questions

What kind of medications will I get?

Advanced injectable, oral, and topical longevity medications that treat the cellular causes of skin aging. Your physician selects and doses your prescription protocol from your Clinical Skin Analysis, and you’ll see your exact medications before you commit to anything.

Do I need a prescription?

Yes, your treatment requires a prescription — and the program includes it. Oona physicians, all licensed in the United States, will conduct a thorough review of your health profile to assess your suitability. Upon approval, they write your prescription, and a licensed U.S. pharmacy compounds your treatment.

Is it safe to take these with my current medications?

Your intake covers your medical history and current medications, and your physician reviews everything before prescribing. If the protocol isn’t right for you, you won’t be charged.

Do I have to change my current routine?

No. Your physician reviews any medications you take, prescription skincare included, before writing your protocol. As with any new topical, start yours on its own and let your skin settle before layering it back in with the rest of your routine.

What side effects should I expect?

Some side effects are common when starting any new medication, and they usually fade as your body adjusts. Your physician starts you on conservative doses based on your Clinical Skin Analysis, and can adjust your protocol as needed.

How is my treatment monitored over time?

Your physician sets your starting doses, reviews them when your DNA results come in, and adjusts them if your skin or a side effect calls for it. If you have any questions, message your care team any time, and they’ll pass anything medical to your physician.

How accurate are my DNA results?

Your sample is analyzed in a CLIA-certified, CAP-accredited U.S. lab that sequences your genome and decodes more than 70 million variants with 99% accuracy.2 Your report uses the 54 linked to skin aging.

How is my DNA data kept private?

Your DNA data is encrypted and never sold. It’s shared only with the lab that analyzes your sample, the physician who sets your prescription protocol, and the partner that makes your supplements. You can request deletion at any time.

Do I have control over my genetic information?

Absolutely. You control how your genetic information is used, shared, and when it is deleted.

Is my DNA data secure?

Yes. Your genetic information is encrypted. Your DNA sample and genetic information are secure with Oona and our CLIA-certified, CAP-accredited laboratory partner.

Can I delete my DNA from your system?

Yes. Your DNA & Methylation Test results are stored in a secured database. Your DNA sample is destroyed after testing and quality control checks, and you can ask us to delete your data from our systems at any time.

Will my DNA be used for research?

No. We will not use your genetic information for research.

Is this covered by insurance?

Oona’s programs aren’t billed to insurance. You can ask your insurance provider whether you can file for reimbursement, and we’re happy to provide the paperwork. Just reach out to concierge@withoona.com.

Are my personalized supplements made unique to me?

Yes. Your supplements respond to your methylation, so every order is one of a kind. Each nutrient is chosen from clinical research for better sleep, less stress, and healthier skin.

What ingredient types are included in my personalized supplements?

Your supplements combine vitamins, minerals, amino acids, herbs, and food extracts. A typical daily pack contains 20+ ingredients, and your exact mix depends on your methylation results.

Once I get my test results, when do I get my supplements?

After your results are released, processing for your personalized supplements begins — there’s no action you need to take. They ship once they’re made.

Reverse your Skin Age. Start today.

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